Our lab investigates how brain complexity is achieved, impaired, and exploited in disease by focusing on the causal role of cell morphology in cellular function. We challenge classical views in cell biology by testing whether cellular form is not merely a byproduct, but a driver of function in brain development, evolution and pathology. Through our work we aim to reframe understanding of brain development and disease and to advance translational insight into unmet clinical challenges, particularly Down syndrome, glioblastoma and neurofibromatosis type 1.

To achieve this, we integrate cell biology, genomics, and computational approaches across complementary model systems (cortical organoids, in vivo models, patient samples and patient-derived glioblastoma organoids), spanning molecular to evolutionary scales, while anchoring our insights at the cellular level.

We value interdisciplinary and collaborative science, diversity of thinking and the courage to ask bold questions. We combine hypothesis-driven and curiosity-driven research and are committed to integrity, inclusion and open science.

Training is central to our mission and we foster intellectual independence, conceptual depth and thoughtful risk-taking in our trainees.